How a Robust, Fully Integrated, and Highly Vetted Cell-Line Development...
Sherry Gu, senior vice president of CMC management, WuXi Biologics. Since 2020, WuXi Biologics has supported process development and manufacturing for more than 30 biopharmaceuticals associated with...
View ArticleTwenty Years of Innovation: Reflections on the Industry’s Past and Future
In honor of BPI’s 20th anniversary as a publication, the editors invited authors to reflect on the industry’s past, present, and future. Below, the chief operating officer of Selexis offers her...
View ArticleRapid Identification of Stable Biologic Candidates During Cell Line Development
There’s no doubt that CHO cell lines are being pushed to their limits: Newer and more complex biologic modalities have low expression yield Dramatically higher concentration requirements of injectables...
View ArticleTargeting RNA: How Epitranscriptomics Can Improve Productivity
Cell-line development traditionally has focused on genetic engineering of chromosomal DNA in cellular nuclei. Combining technological advances such as zinc-finger nucleases (ZFNs) and transcription...
View ArticleCell Lines Are the Foundation: A Methodical Approach to Derisking Outsourced...
The most important choice for bringing a novel biologic into clinical development could be the cell line for expressing it. Somewhat determined by that, development of the initial manufacturing process...
View ArticleIntroduction: Cell-Line Development Discussions at Biotech Week Boston
The genetic sequence of the Chinese hamster ovary (CHO) cell line first was published just over a decade ago (1, 2). As with the Human Genome Project, genomic knowledge of that and other...
View ArticleBuilding the Next Generation of Cell-Line–Development Platforms
Speed to market is a critical business driver in the biopharmaceutical industry. However, drug development success also requires building a robust process that maximizes efficiency while limiting the...
View ArticleBenefits of a Customized Cell Line Development Program
Cell line development at Just-Evotec Biologics is focused on lowering the cost of manufacturing and creating highly productive cell lines for our clients and partners. To achieve this, we leverage our...
View ArticleEngineering the Future: Cell-Line Development Discussions at BPI West
Big data, next-generation sequencing (NGS), automation, and powerful analytical technologies are helping biopharmaceutical companies achieve the parallel goals of cell-line development: precise...
View ArticleUnlocking the Potential of CHO Cells: Advancing Bioproduction with...
traditional cell line development to support bioprocessing often has relied on a “one-size-fits-all” vector, which can lead to suboptimal expression levels in Chinese hamster ovary (CHO) cell cultures....
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